Reversal of multidrug resistance of hepatocellular carcinoma cells by metformin through inhibiting NF-κB gene transcription

Figure 4 Alteration of P-glycoprotein expression in cells treated with metformin plus nuclear factor-κB-small interference RNA. A: Alteration of P-gp expression in different groups of cells. A significant decrease of P-gp expression analyzed by Western blot was found in HepG2/ADM cells treated with the metformin plus NF-κB-siRNA; B: The gray intensity images of Figure 4A. ^bP < 0.01 vs the blank group (n = 3, mean ± SD). P-gp: P-glycoprotein; NF-κB: Nuclear factor-κB; ADM: Adriamycin; siRNA: Small interference RNA.