Binge ethanol intake in chronically exposed rat liver decreases LDL-receptor and increases angiotensinogen gene expression

Figure 3 Levels of phosphorylated ERK1/2 (A/C) and ERK1/2 (B/D) protein in nuclear extracts in chronic and chronic-binge treated rats. The chronic ethanol feeding (4 wk) and binge (single) treatment was as in Figure 1. The nuclear extracts from liver were subjected to western blotting with respective antibodies, followed by densitometry of bands (see methods). Values are mean ± SD (n = 4). ^aP < 0.05 vs control; ^cP < 0.05 vs chronic ethanol group. C: Control (pair fed); E: Chronic ethanol; E-B: Chronic-ethanol binge.