Pentadecapeptide BPC 157 resolves Pringle maneuver in rats, both ischemia and reperfusion

Figure 8 BPC 157 effect on liver gross presentation (left, Ic5, Ic15, Ic30, Rci, Rc15, IB5, IB15, IB30, RBi, RB15) and liver microscopy [right, Ic30, Rc15, Rc24 h, IB30, RB15, RB24 h (white letters)] presentation. Liver gross presentation. Yellowish liver presentation in control rats at 5 min (Ic5), 15 min (Ic15) and 30 min (Ic30) portal triad obstruction (PTO)-ligation time and in reperfusion with pale areas, immediately after medication (Rci) and at 15 min reperfusion time (Rc15); BPC 157 application markedly attenuated these changes, during PTO (IB5, IB15, IB30) as well as in reperfusion time (RBi, RB15) (see Figure 7). Liver microscopy (HE staining, × 10). Controls. Substantial congestion of central vein as well as branches of terminal portal venules present at the end of 30 min PTO ischemia period (Ic30). With reperfusion, as seen at 15 min of reperfusion (Rc15) as well as at 24 h of reperfusion, substantial congestion of central vein as well as branches of terminal portal venules remained (Rc24 h). BPC 157. Substantial congestion of central vein as well as branches of terminal portal venules counteracted at the end of 30 min PTO ischemia period (IB30). With reperfusion, as seen at 15 min of reperfusion (RB15) as well as at 24 h of reperfusion (RB24 h), the reversal of substantial congestion of central vein as well as branches of terminal portal venules.