Pentadecapeptide BPC 157 resolves Pringle maneuver in rats, both ischemia and reperfusion

Figure 5 BPC 157 effect on cecal vessels (left, Ic5, Ic15, Ic30, Rci, Rc15, IB5, IB15, IB30, RBi, RB15) and azygos veins [right, Ic30, Rc15, Rc24 h, IB30, RB15, RB24 h (white letters)] presentation. Presentation of cecal vessels. Controls with veins congestion and tortuosity at 5 min (Ic5), 15 min (Ic15) and 30 min (Ic30) portal triad obstruction (PTO)-ligation time, and in reperfusion, immediately (Rci) and at 15 min reperfusion time (Rc15); markedly attenuated veins congestion and tortuosity, increased small vessel branching, “honeycomb” smaller vessel network, in BPC 157 rats 5 min (IB5), 15 min (IB15) and 30 min (IB30) PTO-ligation time, and in reperfusion, immediately (RBi) and at 15 min reperfusion-time (RB15) (Figures 3 and 4). Presentation of azygos veins (yellow ink contrast in inferior caval vein) controls with congestion and tortuosity at 30 min PTO-ligation time (Ic30, scored 2/2/2 Min/Med/Max likely reflecting right heart failure), at 15 min (Rc15, scored 3/3/3) and 24 h (Rc24 h, scored 3/3/3) in reperfusion time, likely reflecting persisting right heart failure. Marked attenuation occurs in BPC 157 rats at 30 min PTO-ligation time [IB30, scored 1/1/1 (µg), 1/1/1 (ng), ^aP < 0.05, at least vs control] and in reperfusion, at 15 min (RB15, scored 1/1/1 (µg), 1/1/1 (ng), ^aP < 0.05, at least vs control) and at 24 h [RB 24 h, scored 1/1/1 (µg), 1/1/1 (ng), ^aP < 0.05, at least vs control] reperfusion-time.