Immunomodulatory oligonucleotide IMT504: Effects on mesenchymal stem cells as a first-in-class immunoprotective/immunoregenerative therapy

doi:10.4252/wjsc.v9.i3.45

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World Journal of Stem Cells

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1948-0210

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World J Stem Cells. Mar 26, 2017; 9(3): 45-67
Published online Mar 26, 2017. doi: 10.4252/wjsc.v9.i3.45

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Figure 5 IMT504 protects neutropenic animals from fatal Pseudomonas aeruginosa bacteremia and sepsis. Kaplan-Meier survival plot representing IMT504 monotherapy vs antibiotic (cefepime) monotherapy vs control. IMT504 daily doses were started at day 5 after bacterial infection. Arrows indicate IMT504 treatment, which consisted of subcutaneous injections containing 50 g of IMT504 over 5 successive days. Experimental details described in Chahin et al[363].

Citation: Zorzopulos J, Opal SM, Hernando-Insúa A, Rodriguez JM, Elías F, Fló J, López RA, Chasseing NA, Lux-Lantos VA, Coronel MF, Franco R, Montaner AD, Horn DL. Immunomodulatory oligonucleotide IMT504: Effects on mesenchymal stem cells as a first-in-class immunoprotective/immunoregenerative therapy. World J Stem Cells 2017; 9(3): 45-67
URL: https://www.wjgnet.com/1948-0210/full/v9/i3/45.htm
DOI: https://dx.doi.org/10.4252/wjsc.v9.i3.45