Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment

Figure 19 Hybrids of cancer cells with normal cells or monocyte derived cells contribute to the lack of cancer rejection and its progression. The malignant and normal cell exhibit a tropism resulting in apposition and a heterokaryon after the fusion with the surface expression of normal cell markers. After deregulated divisions, the multiple hybrid cells persist and some of them can gradually lose normal cell chromosomes and revert back to the malignant stem cells[1].