Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment

Figure 14 In vitro developed oocyte-like cells retrieve meiotically nonfunctional organelles from fibroblasts or satellite daughter cells. A: The in vitro developed oocyte-like cell (OLC) (o) with a lack of optically dense organelles (bold white arrow) is joined (arrowhead) by a fibroblast (fb) which provides organelles (B), but forms a fibro-oocyte hybrid causing oocyte regression (C); Alternatively, the OLC forms a satellite daughter (s in D), which is drained (black arrowhead and inset) and regresses (rs in E) when the OLC is saturated (black arrow). This results in the large OLC (F) with germinal vesicle (gv) and thick zona pellucida (zp), but provided organelles are not functional for resuming meiosis II. Panel F reprinted from[10]: ^©Antonin Bukovsky. Other panels adjusted from[50], with a permission: ^©Wiley-Liss, Inc.