Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment

Figure 8 Origin of germ and granulosa cells in the ovary of the human midpregnancy fetus. A: Isolated ovarian stem cell (triangle) is associated with CD14 pMDC (arrowheads); B: Fetal germ cells (red triangles) lacking MHC-I expression originate from MHC-I+ ovarian stem cells (white triangles); C: The symmetric division of germ cells (blue triangles) follows asymmetric division (white and red triangles) of ovarian stem cells, and causes emergence of moving germ cell (mgc); D: The origin of germ cells requires association of CD8⁺ (D) and DR⁺ (E) T cell; F: Meiosis I telophase (red triangles) is associated with a primitive MDC (arrowhead); G: The fetal primitive granulosa cells (pgrc) originate from ovarian stem cells between the mesenchymal cell cords (mcc); H: Small growing follicle (gf) is accompanied by DR⁺ MDCs (arrows), which are absent at the resting follicle (rf). Inset shows Thy-1⁺ pericytes (arrowhead) during follicular selection (Figure 7). Bar in A for A-F. Adjusted from[44] with a permission: ^©Springer United States. MDC: Monocyte-derived cell; pMDC: Primitive MDC.