In vivo imaging of endogenous neural stem cells in the adult brain

Figure 2 [¹⁸F]FLT labels proliferating endogenous neural stem cell in the neurogenic niches of the healthy rodent brain. A, A’: eNSC proliferation in the subventricular zone of adult rats as assessed by [¹⁸F]FLT-PET; B: The signal corresponds to BrdU-positive cells in the region; C: Activation of eNSC by pharmacological stimulation with fibroblast growth factor 2, delta-like 4, and insulin is visualized with [¹⁸F]FLT-PET. eNSC: Endogenous neural stem cell; [¹⁸F]FLT-PET: 3’-deoxy-3’-[¹⁸F]fluoro-L-thymidine-positron emission tomography; i.c.v.: Intracerebroventricular application. Adapted from Rueger et al[75], with permission.