Mesenchymal stem cells for treatment of aortic aneurysms

Figure 1 Diagram of bone marrow-derived mesenchymal stem cell cell-sheet implantation or bone marrow-derived mesenchymal stem cell intravenous-administration protocol. At the time of Alzet osmotic minipump implantation, the BM-MSC cell-sheet was implanted into the nearby abdominal aortic adventitia[51], and 1 × 106 BM-MSCs (in 0.2 mL saline) or 0.2 mL saline were injected intravenously via the tail vein every week[53]. Mice were sacrificed and assessed on day 28. ATII: Angiotensin II; iv: Intravenous; BM-MSC: Bone marrow-derived mesenchymal stem cell.