Human pluripotent stem cell-derived β cells: Truly immature islet β cells for type 1 diabetes therapy?

doi:10.4252/wjsc.v15.i4.182

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Apr 26, 2023 (publication date) through Jul 30, 2024

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Apr 26, 2023; 15(4): 182-195
Published online Apr 26, 2023. doi: 10.4252/wjsc.v15.i4.182

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Figure 3 There are clear differences in spatiotemporal and microenvironment niches between the in vivo development and ex vivo differentiation of islet lineages. Details of lineage tracing mouse lines can be found in articles[103,104]. ICM: Inner cell mass; PSC: Pluripotent stem cell; Sox17: SRY-box transcription factor 17; GFP: Green fluorescent protein; PDX1: Pancreatic and duodenal homeobox 1, also known as insulin promoter factor 1; NGN3: Neurogenin-3; MIP: Mouse insulin 1 promoter; SC-β cells: Stem cell-derived β cells.

Citation: Jiang H, Jiang FX. Human pluripotent stem cell-derived β cells: Truly immature islet β cells for type 1 diabetes therapy? World J Stem Cells 2023; 15(4): 182-195
URL: https://www.wjgnet.com/1948-0210/full/v15/i4/182.htm
DOI: https://dx.doi.org/10.4252/wjsc.v15.i4.182