Recent clinical trials and optical control as a potential strategy to develop microtubule-targeting drugs in colorectal cancer management

Table 1 Recruiting colorectal cancer clinical trials that include paclitaxel

Clinical trial number	Treatment	Stage	Country
NCT05185947	Paclitaxel + nilotinib	Phase II	United States
NCT04731467	Nivolumab, Nab-paclitaxel, gemcitabine	Phase I/II	United States, Spain
NCT03129139	Minnelide™ + protein-bound paclitaxel	Phase I	United States
NCT05453825	Navicixizumab + paclitaxel or irinotecan	Phase II	United States
NCT05107674	NX-1607 (+ paclitaxel)	Phase Ia/b	United States, United Kingdom
NCT03678883	9-ING-41, gemcitabine, doxorubicin, carboplatin, Nab-paclitaxel, paclitaxel, irinotecan	Phase II	United States, Belgium, Canada, France, Netherlands, Portugal, Spain
NCT05395910	Paclitaxel	Phase I	Singapore (note: Peritoneal carcinomatosis)
NCT04666688	LYT-200, tislelizumab, gemcitabine + Nab-paclitaxel	Phase I/II	United States
NCT04444921	Carboplatin, nivolumab, paclitaxel	Phase III	United States (note: Anal cancer)
NCT04083599	GEN1042, pembrolizumab, cisplatin, carboplatin, 5-FU, gemcitabine, Nab-paclitaxel, pemetrexed, paclitaxel	Phase I/II	United States, Denmark, France, Georgia, Germany, Israel, Italy, Republic of Korea, Republic of Moldova, Spain, Taiwan, United Kingdom
NCT03872947	TRK-950, irinotecan, leucovorin, 5-FU, gemcitabine, cisplatin, carboplatin, ramucirumab, paclitaxel, nivlumab, pembrolizumab, imiquimod cream, bevacizumab, topotecan, PCD	Phase I	United States, France
NCT04644068	ADZ5305, paclitaxel, carboplatin, T-Dxd, Dato-DXd, camizestrant	Phase I/II	United States, Australia, Canada, China, Czechia, Hungary, Italy, Japan, Republic of Korea, Poland, Russian Federation, Spain, United Kingdom
NCT06047379	NEO212, ipilimumab, pembrolizumab, nivolumab, regorafenib, carboplatin, paclitaxel, FOLFIRI, bevacizumab	Phase I/II	United States