Recent clinical trials and optical control as a potential strategy to develop microtubule-targeting drugs in colorectal cancer management

doi:10.3748/wjg.v30.i13.1780

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 7, 2024; 30(13): 1780-1790
Published online Apr 7, 2024. doi: 10.3748/wjg.v30.i13.1780

Recent clinical trials and optical control as a potential strategy to develop microtubule-targeting drugs in colorectal cancer management

Katsuhiro Kita, Allen Burdowski

Katsuhiro Kita, Allen Burdowski, Department of Biology, St. Francis College, Brooklyn, NY 11201, United States

Author contributions: Kita K and Burdowski A conceived the idea and wrote the manuscript.

Conflict-of-interest statement: The author declares no conflict of interests.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Katsuhiro Kita, PhD, Assistant Professor, Department of Biology, St. Francis College, 179 Livingston Street, Brooklyn, NY 11201, United States. kkita@sfc.edu

Received: December 27, 2023
Peer-review started: December 27, 2023
First decision: January 10, 2024
Revised: February 8, 2024
Accepted: March 19, 2024
Article in press: March 19, 2024
Published online: April 7, 2024

Core Tip

Core Tip: This review article proposes a potentially new approach to utilize photo-switchable microtubule (MT)-targeting drugs in colorectal cancer (CRC). First, we will start the introduction of CRC and current therapy as well as some updates in 2023. Then, we list a popular MT-targeting drug family, taxanes in CRC. As many readers may be aware, taxanes are not really effective in CRC for some reason. Here, we would like to shed light on optically controllable MT-targeting drugs as potential new drug candidates in CRC management.