Poly(A)-specific ribonuclease protein promotes the proliferation, invasion and migration of esophageal cancer cells

Figure 2 Poly(A)-specific ribonuclease protein expression was upregulated in both esophageal cancer tissue and cell lines and correlated with poor prognosis in esophageal cancer patients. A: Left panel: Representative immunohistochemistry (IHC) staining images of poly(A)-specific ribonuclease (PARN) in esophageal cancer tissue specimens (magnification × 400, bar = 50 μm). Right panel: Summary of IHC staining of PARN in esophageal cancer tissues (n = 91) and adjacent normal tissues (n = 63) in an esophageal tissue microarray; B: PARN mRNA levels were significantly increased in esophageal cancer tissue (n = 160) compared with adjacent normal tissues (n = 11). The data were obtained from The Cancer Genome Atlas; C: Kaplan-Meier survival analysis showed that high expression of PARN was correlated with poor prognosis in esophageal cancer patients (the PARN IHC score criteria: Table 5); D and E: Exploration of PARN gene expression in various malignant tumors using TCGA database, and the expression of PARN gene in EC was significantly higher than that in adjacent tissues in the TCGA database, P = 0.0004; F: PARN mRNA levels in esophageal cancer cell lines. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, mean ± SD is shown. PARN: Poly(A)-specific ribonuclease; IHC: Immunohistochemistry.