Overview of current detection methods and microRNA potential in Clostridioides difficile infection screening

Figure 2 Pathogenicity loci of toxicogenic Clostridioidesdifficile. The 19.6 kbp long pathogenicity loci in toxicogenic Clostridioides difficile, including tcdC, tcdA, tcdE, tcdB and tcdR coding genes. tcdR codes for an RNA polymerase sigma factor that controls the expression of the tcdB and tcdA genes and possibly tcdE. The transcription of tcdR can be regulated by three promoters. One is under the control of σ^D, and the other two are autoregulatory tandem promoters. Figure adopted and modified from Isidro et al[19].