Application of nanotechnology in reversing therapeutic resistance and controlling metastasis of colorectal cancer

Figure 6 Nanomedicine targeted myeloid-derived suppressive cells exhibited synergistic inhibitory effect on colorectal cancer growth with radiotherapy and PD-L1 blockade. A: Schematic illustration of synthesis of HMP nanoparticles and drug loading; B: IPI549@HMP treatment improved hypoxia environment (left), and augmented radiotherapy efficacy; C: Kaplan-Meier survival curves and tumor growth curves of each groups. Citation: Guan X, Sun L, Shen Y, Jin F, Bo X, Zhu C, Han X, Li X, Chen Y, Xu H, Yue W. Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis. Nat Commun 2022; 13: 2834[16]. Copyright ©The Author(s) 2022. Reprinted permission from Springer Nature Publications. The authors have obtained the permission for figure using from the Springer Nature Publications (Supplementary material).