Application of nanotechnology in reversing therapeutic resistance and controlling metastasis of colorectal cancer

Figure 3 Nanoemulsioned Paclitaxel and BEZ235 reduced multidrug resistance of colorectal cancer. A: Morphological changes of cells treated with nanoemulsioned Paclitaxel and BEZ235; B: Downregulated expression of P-gp after NE-PTX and BEZ235 treatment; C: Synergistic inhibition of CRC growth in vivo. Citation: Hu Y, Zhang K, Zhu X, Zheng X, Wang C, Niu X, Jiang T, Ji X, Zhao W, Pang L, Qi Y, Li F, Li L, Xu Z, Gu W, Zou H. Synergistic Inhibition of Drug-Resistant Colon Cancer Growth with PI3K/mTOR Dual Inhibitor BEZ235 and Nano-Emulsioned Paclitaxel via Reducing Multidrug Resistance and Promoting Apoptosis. Int J Nanomedicine 2021; 16: 2173-2186[214]. Copyright ©The Author(s) 2021. Published by Dove Medical Press Ltd. The authors have obtained the permission for figure using from the Dove Medical Press Ltd. (Supplementary material).