Advances in medical treatment for pancreatic neuroendocrine neoplasms

Figure 1 History and key events in the development of pancreatic neuroendocrine neoplasms systemic therapy. PRRT: Peptide receptor radionuclide therapy; SSAs: Somatostatin analogs; PD-L1: Programmed cell death-ligand 1 inhibitor; PD-1: Programmed cell death-1 inhibitor; CTLA-4: Cytotoxic T-lymphocyte antigen 4 inhibitor; STZ: Streptozotocin; CAPTEM: Capecitabine and temozolomide regimen; PROMID[13], NCT00171873; CLARINET[14], NCT00353496; SUN.III[15], NCT00428597; RADIANT-3[16], NCT00510068; SANET-P[17], NCT02589821; NETTER-1[18], NCT01578239.