Effect of acetyl-L-carnitine on hypersensitivity in acute recurrent caerulein-induced pancreatitis and microglial activation along the brain’s pain circuitry

Figure 5 Enlarged microglial cells were measured in the dentate gyrus of mice with caerulein-induced pancreatitis compared to control samples. A: The analyzed area is outlined in yellow in an overview of the mouse brain at bregma -2.18 mm, interaural 1.62 mm[50,51]; B and C: Microglia in the dentate gyrus of naïve control and in the caerulein- (CAE) induced pancreatitis mice were measured; D-G: Microglial convex (examples circled in red in B and C) and (F) somal area were significantly enlarged after 6 wk of CAE-induced pancreatitis while (E and G) intensity of ionized calcium-binding adaptor molecule 1 (Iba1) immunoreactivity was unchanged. Naïve control n = 4, CAE + VEH n = 5, ^aP < 0.05 Student’s t-test. CAE: Caerulein; VEH: Vehicle.