Metabolomics of Fuzi-Gancao in CCl4 induced acute liver injury and its regulatory effect on bile acid profile in rats

Table 6 Variable importance in the projection values of serum metabolites and effects of CCl₄ on their changes (model group vs negative group)

Var ID (primary)	M1-VIP	Variation trend
GSSG	1.19631	↑↑
Cholic acid	1.18964	↑↑
Uridine	1.18609	↑↑
N-phenylacetylglycine	1.16986	↑↑
Hypoxanthine	1.13469	↑↑
(E)-butenedioic acid	1.1299	↑↑
GSH	1.12862	↑↑
C18:0LPC	1.12325	↓↓
Pantothenic acid	1.08663	↑↑
Carnitine	1.08264	↑↑
Phenylalanine	1.07794	↑↑
Hippuric acid	1.06083	↑↑
C16:1LPC	1.05866	↓↓
Uric acid	1.01621	↑↑
C18:1LPC	0.943612	↓↓
L-kynurenine	0.919692	↑
L-leucine	0.90164	↑↑
Glucosamine-1-phosphate	0.893372	↑
Citric acid	0.866932	↓↓
L-tryptophan	0.842517	↑
8-OH-dG	0.711595	↑
Lactate	0.704198	NS
Choline	0.639509	NS
C16:0LPC	0.514772	NS

↑ represents a P value ≤ 0.05 for the increase in mean content; ↑↑ represents a P value ≤ 0.01 for the increase in mean content; ↓ represents a P value ≤ 0.05 for the mean content decrease; ↓↓ represents a P value ≤ 0.01 for the mean content decrease; NS: The mean concentrations of metabolites in the model group were not statistically significant; GSSG: Glutathione oxidized; GSH: Glutathione; VIP: Variable importance in the projection.