Pleiotropy within gene variants associated with nonalcoholic fatty liver disease and traits of the hematopoietic system

Figure 5 Overrepresentation analysis of biological pathways of genes associated with platelet count vs. genes associated with nonalcoholic fatty liver disease. Overrepresentation analysis of biological pathways of platelet count-associated genes in comparison with that pertaining to nonalcoholic fatty liver disease-associated genes. The input list of platelet count-associated variants (P < 1 × 10^-6) was generated by searching the United Kingdom Biobank genome-wide association studies database as provided by Neale’s lab resource (http://www.nealelab.is/uk-biobank/). The input list associated with nonalcoholic fatty liver disease includes 928 genes/proteins obtained by data mining[5]. The analysis was performed by applying the functional enrichment and interaction network analysis (FunRich) tool[46].