High levels of serum interleukin-6 increase mortality of hepatitis B virus-associated acute-on-chronic liver failure

Table 5 Mortality according to the dynamic changes in interleukin-6 within 4 wk

	Mortality	HR (95%CI)	P value	P value for trend
Group A (n = 60)	3 (5.0%)	1		0.023
Group B (n = 106)	8 (7.5%)	1.53 (0.41-5.78)	0.528
Group C (n = 26)	3 (11.5%)	2.41 (0.49-12.0)	0.281
Group D (n = 54)	9 (16.7%)	2.80 (0.72-10.83)	0.136

P values shown in bold indicate statistical significance. A: Patients with high interleukin 6 (IL-6) levels at baseline and low IL-6 levels at 4 wk; B: Patients with low IL-6 levels both at baseline and at 4 wk; C: Patients with low IL-6 levels at baseline and high IL-6 levels at 4 wk; D: Patients with high IL-6 levels both at baseline and at 4 wk. HR: Hazard ratio; CI: Confidence interval.