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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 14, 2020; 26(30): 4479-4488
Published online Aug 14, 2020. doi: 10.3748/wjg.v26.i30.4479
Published online Aug 14, 2020. doi: 10.3748/wjg.v26.i30.4479
High levels of serum interleukin-6 increase mortality of hepatitis B virus-associated acute-on-chronic liver failure
Chao Zhou, Ning Zhang, Ting-Ting He, Yao Wang, Li-Fu Wang, Yong-Qiang Sun, Jing Jing, Jing-Jing Zhang, Shuang-Nan Fu, Xuan Wang, Xiao-Xiao Liang, Xin Li, Man Gong, Jun Li, Department of Integrative Medicine, 5th Medical Center of Chinese PLA General Hospital, Beijing 100039, China
Author contributions: Gong M, Li J, and Wang LF conceptualized the study; Zhou C, Zhang N, Sun YQ, Wang Y, and He TT collected the data; Zhou C, Jing J, and Li X performed statistical analysis; Zhang JJ, Wang X, Fu SN, and Liang XX were involved in drafting of the manuscript; all authors revised the manuscript for important intellectual content and approved the final version of the manuscript.
Supported by National Thirteen Five-year Science and Technology Major Project of China , No. 2018ZX10725506-002 ; and National Twelve Five-year Science and Technology Major Project of China , No. 2012ZX10005-005 .
Institutional review board statement: The study was reviewed and approved by the ethics committee of the 302 Military Hospital of China (2012 Aug 22).
Informed consent statement: The need for written informed consent was waived by the ethics committee for this study.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Man Gong, MD, Associate Professor, Department of Integrative Medicine, 5th Medical Center of Chinese PLA General Hospital, No. 100 the 4th Ring Road, Beijing 100039, China. gongman302@163.com
Received: April 22, 2020
Peer-review started: April 22, 2020
First decision: June 13, 2020
Revised: June 24, 2020
Accepted: July 16, 2020
Article in press: July 16, 2020
Published online: August 14, 2020
Peer-review started: April 22, 2020
First decision: June 13, 2020
Revised: June 24, 2020
Accepted: July 16, 2020
Article in press: July 16, 2020
Published online: August 14, 2020
Core Tip
Core tip: To triage and prognosticate the outcome is vital for management of patients with hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF). Interleukin-6 (IL-6) is related with the physiology and pathology of the liver. We found that a high level of serum IL-6 was an independent risk factor for mortality in patients with HBV-ACLF. HBV-ACLF patients with high levels of IL-6 showed a high mortality, especially in those with persistent high levels within 4 wk, indicating that IL-6 is an index of prognosis for HBV-ACLF.