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©The Author(s) 2020.
World J Gastroenterol. Jan 14, 2020; 26(2): 184-198
Published online Jan 14, 2020. doi: 10.3748/wjg.v26.i2.184
Published online Jan 14, 2020. doi: 10.3748/wjg.v26.i2.184
Figure 6 Effect of GFRA1b overexpression on the phosphorylation and expression levels of AKT and ERK proteins in colon cancer cells.
A: GDNF-GFRA1-related downstream RET-RAS-PI3K-AKT and RET-RAS-RAF1-MEK1/2-ERK1/2 signaling pathways[6-8]; B: Phosphorylation and expression levels of AKT and ERK proteins in RKO and HCT116 cells with and without GFRA1 overexpression by Western blot. p-AKT and p-ERK represent phosphorylated AKT and ERK proteins, respectively.
- Citation: Ma WR, Xu P, Liu ZJ, Zhou J, Gu LK, Zhang J, Deng DJ. Impact of GFRA1 gene reactivation by DNA demethylation on prognosis of patients with metastatic colon cancer. World J Gastroenterol 2020; 26(2): 184-198
- URL: https://www.wjgnet.com/1007-9327/full/v26/i2/184.htm
- DOI: https://dx.doi.org/10.3748/wjg.v26.i2.184