Effect of low-dose aspirin administration on long-term survival of cirrhotic patients after splenectomy: A retrospective single-center study

Table 2 Univariate and multivariate analyses of risk factors for the development of hepatocellular carcinoma after splenectomy

Variable	Univariate analysis		Multivariate analysis
	P-value	OR (95%CI)	P-value	OR (95%CI)
Gender (male/female)	0.067	2.348 (0.942-5.853)	0.088	2.287 (0.884-5.919)
Age > 60 yr	0.946	1.045 (0.292-3.742)
Hypertension (yes/no)	0.222	0.628 (0.298-1.325)
Diabetes (yes/no)	0.187	3.941 (0.514-30.211)
Drinking (yes/no)	0.432	0.689 (0.276-1.717)
Smoking (yes/no)	0.791	0.902 (0.421-1.933)
Platelet count at admission (< 30 × 109/L)	0.434	1.337 (0.646-2.764)
ALT (> 40 U/L)	0.543	1.237 (0.632-2.459)
AST (> 40 U/L)	0.063	1.910 (0.966-3.775)	0.323	1.460 (0.690-3.092)
Albumin (< 35 g/L)	0.155	0.612 (0.312-1.203)
Total bilirubin (> 17 μmol/L)	0.683	1.169 (0.553-2.471)
PT (> 17 s)	0.581	1.221 (0.601-2.477)
APTT (> 45 s)	0.297	1.452 (0.721-2.924)
INR (> 1.2)	0.063	2.555 (0.949-6.881)	0.077	2.496 (0.904-6.892)
Child-Pugh score	0.106	1.218 (0.959-1.548)
Surgical method (LS vs OS)	0.094	0.285 (0.066-1.236)	0.297	0.446 (0.098-2.033)
Intraoperative blood loss (mL)	0.184	0.998 (0.995-1.001)
Spleen volume (mm3)	0.994	1.000 (1.000-1.000)
Spleen size (mm)	0.129	0.993 (0.983-1.002)
Postoperative early aspirin (yes/no)	0.010	6.696 (1.567-28.616)	0.016	6.211 (1.412-27.324)

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; PT: Prothrombin time; APTT: Activated partial thromboplatin time; INR: International normalized ratio; LS: Laparoscopic surgery; OS: Open surgery.