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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 28, 2019; 25(28): 3798-3807
Published online Jul 28, 2019. doi: 10.3748/wjg.v25.i28.3798
Published online Jul 28, 2019. doi: 10.3748/wjg.v25.i28.3798
Effect of low-dose aspirin administration on long-term survival of cirrhotic patients after splenectomy: A retrospective single-center study
Zhao-Qing Du, Jun-Zhou Zhao, Jian Dong, Jian-Bin Bi, Yi-Fan Ren, Jia Zhang, Bilawal Khalid, Yi Lv, Xu-Feng Zhang, Rong-Qian Wu, National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Zhao-Qing Du, Jun-Zhou Zhao, Jian Dong, Jian-Bin Bi, Yi-Fan Ren, Jia Zhang, Bilawal Khalid, Zheng Wu, Yi Lv, Xu-Feng Zhang, Rong-Qian Wu, Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Author contributions: All authors contributed to the study; Du ZQ wrote the manuscript, and collected and analysed the data; Zhao JZ collected and analysed the data, and contributed to the follow-up results; Bi JB, Ren YF, and Zhang J collected the data and performed the analysis; Bilawal K contributed to the data; Wu Z and Lv Y provided the resources and supervision; Zhang XF and Wu RQ contributed to writing the manuscript, and drafting the conception and design. All authors read and approved the final manuscript.
Supported by the Ministry of Education Innovation Team Development Program of China , No. IRT16R57 .
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the First Affiliated Hospital of Xi'an Jiaotong University (Permit number: XJTU1AF2015LSL-057).
Informed consent statement: Written informed consent from the patients was waived due to the retrospective nature of this study.
Conflict-of-interest statement: All authors declare no conflicts of interest related to this article.
Data sharing statement: No additional data are available.
Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Rong-Qian Wu, MD, PhD, Professor, National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, First Affiliated Hospital of Xi’an Jiaotong University, 76 West Yanta Road, P.O. Box 124, Xi’an 710061, Shaanxi Province, China. rwu001@mail.xjtu.edu.cn
Telephone: +86-29-85323204 Fax: +86-29-85252580
Received: April 3, 2019
Peer-review started: April 3, 2019
First decision: May 30, 2019
Revised: June 4, 2019
Accepted: June 22, 2019
Article in press: June 23, 2019
Published online: July 28, 2019
Peer-review started: April 3, 2019
First decision: May 30, 2019
Revised: June 4, 2019
Accepted: June 22, 2019
Article in press: June 23, 2019
Published online: July 28, 2019
Core Tip
Core tip: Anticoagulant therapy reduces the incidence of post-splenectomy portal thrombosis and improves prognosis by inhibiting thrombus formation. This study was to investigate the effect of postoperative long-term low-dose aspirin therapy on the development of hepatocellular carcinoma and long-term survival of cirrhotic patients after splenectomy. Post-splenectomy long-term administration of low-dose aspirin reduced the incidence of hepatocellular carcinoma and improved the long-term overall survival in patients with viral hepatitis-related cirrhosis. Thus, long-term low-dose aspirin therapy should be recommended to cirrhotic patients with hypersplenism after splenectomy.