Influence of NUDT15 variants on hematological pictures of patients with inflammatory bowel disease treated with thiopurines

Figure 4 Effect of thipourine on mean corpuscular volume. A: MCV in Groups A + B + C vs D. MCV increased after starting 6MP in both the mutant (Group A + B + C) and the wild cases (Group D, Figure 4). MCV was significantly higher at 10 wk in the mutant than the wild cases (P = 0.0085); B: Increase ratio of MCV in Groups A + B + C vs D. The increase rate was higher in the variants than the wild and statistically significant at 16 wk (P = 0.00198). We set 1.0 as the MCV at the beginning of thiopurines. 6MP: 6-mercaptopurine; MCV: Mean corpuscular volume.