Multiomics biomarkers for the prediction of nonalcoholic fatty liver disease severity

Figure 4 The urea-cycle, glutamate, and branched-chain amino acids in the biology of nonalcoholic fatty liver disease. Sub-network analysis showing the urea-cycle and metabolism of amino acids (L-arginine, L-proline, L-glutamate, L-aspartate and L-asparagine) that were extracted from the interactome shown in Figure 3. Compounds (common names in the Human Metabolome Database, http://www.hmdb.ca), chemical reactions, enzymes (KEGG database) and genes (HUGO symbols) are represented by hexagons, diamonds, squares and circles, respectively.