Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights

Figure 3 Blood vessels after ligation in IC rats (ventral colon side of the colon, before application of medication). A: Progressive disappearance of blood vessels (saline bath, B, ventral colon side; L-NAME, C, dorsal colon side, left) or recovery (BPC 157 bath, B, ventral colon side; L-NAME + BPC 157, C, dorsal colon side, right). Ligation course before therapy (A); ligation course after therapy (B, C). A. Ventral side of the colon showing the presence of an abundant collateral network with inside-outside contact, unlike the relatively scarce arcade collateral network and absent inside-outside contact on the dorsal side (see Figure 2). B. Five minutes later, the number of vessels on the ventral side of the colon is markedly decreased; the inside-outside connection is still present (saline bath, left); or vessel presentation is markedly increased (BPC 157 bath, right). C. From the 10th minute through the end of the 15th minute. Dorsal side of the colon showing progressive vessel disappearance, inside-outside contact largely absent (L-NAME bath, left) (white arrow), unlike recovered blood vessels and inside-outside contact (L-NAME+BPC 157 bath, right (black arrow).