BRAF inhibitor treatment of melanoma causing colonic polyps: An alternative hypothesis

Figure 2 Murine Braf^V637E progression model of intestinal tumorigenesis via the alternative/serrated pathway illustrates the cumulative acquisition of molecular pathway derangement. Intensification of MAP kinase signaling and selective inactivation of genes that govern cellular senescence with progression is a pertinent inference. This figure is based on the model developed by Rad et al[40].