Hepatitis E virus: An ancient hidden enemy in Latin America

Figure 3 A phylogenetic tree for hepatitis E virus according to their amino-acid sequences from the recognition domain E2 (E domain, residues 455 to 606, based on US-1 strain) in the open reading frame capsid protein. This region corresponds with the binding domain of neutralizing Mab 8C11[32,33]. It contains all epitopes demonstrated to elicit neutralizing antibodies. This region is sufficient to provide protection, and is the basis of the current recombinant vaccine Hecolin 293 approved in China. The analysis was based on 100 sequences representing the diversity of HEV sequences. The tree was constructed by the Maximum Likelihood method using PhyML software, as implemented in server http://phylogeny.lirmm.fr[33]. The scale bar represents amino-acid substitutions and the statistical support was obtained from 100 Bootstrap replicates.