Hepatitis E virus: An ancient hidden enemy in Latin America

Figure 2 A schematic representation of the RNA- hepatitis E virus genome. RNA encodes for multiple proteins from three Open Reading Frames (ORFs). ORF1 comprises the methyltransferase (MT), Y domain, a papain-like cysteine protease (PCP), hypervariable region (HVR), X macrodomain, helicase (Hel), and RNA-dependent RNA polymerase (RdRp). ORF 2 encodes the capsid protein, and ORF3 encodes a cytoskeleton-associated phosphoprotein. 5´Cap and 3´PolyA modifications are also depicted. The junction region (JR), stem-loop structure (SL), and cis-reactive element (CRE) have been described elsewhere[12].