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©The Author(s) 2016.
World J Gastroenterol. Nov 7, 2016; 22(41): 9127-9140
Published online Nov 7, 2016. doi: 10.3748/wjg.v22.i41.9127
Published online Nov 7, 2016. doi: 10.3748/wjg.v22.i41.9127
Medication (/kg) given ip (once time daily) or continuously in drinking water (po) after the creation of esophagogastric anastomosis in rats | Esophagitis score (0-5) Min/Med/Max in rats that underwent esophagogastric anastomosis | |||
1 d | 2 d | 3 d | 4 d | |
Min/Med/Max | Min/Med/Max | Min/Med/Max | Min/Med/Max | |
Saline 5 mL | 4/4/4 | 4/4/4 | 4/4/4 | 4/4/4 |
BPC 157 10 μg | 0/1/2a | 0/1/2a | 0/1/2a | 0/1/2a |
L-NAME 5 mg | 5/5/5a | 5/5/5a | 5/5/5a | 5/5/5a |
L-arginine 100 mg | 0/1/2a | 1/2/3a | 1/2/3a | 1/2/3a |
L-NAME 5 mg + L-arginine 100 mg | 2/3/4a | 0/1/2a | 1/2/3a | 1/2/3a |
L-NAME 5 mg + BPC 157 10 μg | 1/2/3a | 1/2/3a | 0/1/2a | 0/1/2a |
L-arginine 100 mg + BPC 157 10 μg | 0/1/2a | 0/1/2a | 0/1/2a | 0/1/2a |
L-NAME 5 mg + L-arginine 100 mg +BPC 157 10 μg | 0/1/2a | 0/1/2a | 1/2/3a | 0/1/2a |
BPC 157 10 ng | 0/1/2a | 0/1/2a | 0/1/2a | 0/1/2a |
L-NAME 5 mg + BPC 157 10 ng | 1/2/3a | 2/3/4a | 1/2/3a | 0/1/2a |
L-arginine 100 mg + BPC 157 10 ng | 0/1/2a | 0/1/2 a | 0/1/2a | 0/1/2a |
L-NAME 5 mg + L-arginine 100 mg +BPC 157 10 ng | 1/2/3a | 0/1/2a | 1/2/3a | 0/1/2a |
Drinking water | 4/4/4 | 4/4/4 | 4/4/4 | 4/4/4 |
12 mL/d per rat | ||||
BPC 157 10 μg | 0/1/2a | 0/1/2a | 0/1/2a | 0/1/2a |
BPC 157 10 ng | 0/1/2a | 0/1/2a | 0/1/2a | 0/1/2a |
- Citation: Djakovic Z, Djakovic I, Cesarec V, Madzarac G, Becejac T, Zukanovic G, Drmic D, Batelja L, Zenko Sever A, Kolenc D, Pajtak A, Knez N, Japjec M, Luetic K, Stancic-Rokotov D, Seiwerth S, Sikiric P. Esophagogastric anastomosis in rats: Improved healing by BPC 157 and L-arginine, aggravated by L-NAME. World J Gastroenterol 2016; 22(41): 9127-9140
- URL: https://www.wjgnet.com/1007-9327/full/v22/i41/9127.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i41.9127