Esophagogastric anastomosis in rats: Improved healing by BPC 157 and L-arginine, aggravated by L-NAME

doi:10.3748/wjg.v22.i41.9127

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 22, Issue 41

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (12615)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-9) series, Tables (1-1) series.

Item

Count

PDF

592

WORD

281

HTML

8082

Figures (1-9)

266

Tables (1-1)

197

Sum=9418

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1370

Download

1827

Sum=3197

Nov 7, 2016 (publication date) through Nov 26, 2024

Times Cited of This Article

Times Cited (19)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastroenterol. Nov 7, 2016; 22(41): 9127-9140
Published online Nov 7, 2016. doi: 10.3748/wjg.v22.i41.9127

Table 1 Esophagitis score (0-5) Min/Med/Max in rats that underwent esophagogastric anastomosis

Medication (/kg) given ip (once time daily) or continuously in drinking water (po) after the creation of esophagogastric anastomosis in rats	Esophagitis score (0-5) Min/Med/Max in rats that underwent esophagogastric anastomosis
	1 d	2 d	3 d	4 d
	Min/Med/Max	Min/Med/Max	Min/Med/Max	Min/Med/Max
Saline 5 mL	4/4/4	4/4/4	4/4/4	4/4/4
BPC 157 10 μg	0/1/2^a	0/1/2^a	0/1/2^a	0/1/2^a
L-NAME 5 mg	5/5/5^a	5/5/5^a	5/5/5^a	5/5/5^a
L-arginine 100 mg	0/1/2^a	1/2/3^a	1/2/3^a	1/2/3^a
L-NAME 5 mg + L-arginine 100 mg	2/3/4^a	0/1/2^a	1/2/3^a	1/2/3^a
L-NAME 5 mg + BPC 157 10 μg	1/2/3^a	1/2/3^a	0/1/2^a	0/1/2^a
L-arginine 100 mg + BPC 157 10 μg	0/1/2^a	0/1/2^a	0/1/2^a	0/1/2^a
L-NAME 5 mg + L-arginine 100 mg +BPC 157 10 μg	0/1/2^a	0/1/2^a	1/2/3^a	0/1/2^a
BPC 157 10 ng	0/1/2^a	0/1/2^a	0/1/2^a	0/1/2^a
L-NAME 5 mg + BPC 157 10 ng	1/2/3^a	2/3/4^a	1/2/3^a	0/1/2^a
L-arginine 100 mg + BPC 157 10 ng	0/1/2^a	0/1/2 ^a	0/1/2^a	0/1/2^a
L-NAME 5 mg + L-arginine 100 mg +BPC 157 10 ng	1/2/3^a	0/1/2^a	1/2/3^a	0/1/2^a
Drinking water	4/4/4	4/4/4	4/4/4	4/4/4
12 mL/d per rat
BPC 157 10 μg	0/1/2^a	0/1/2^a	0/1/2^a	0/1/2^a
BPC 157 10 ng	0/1/2^a	0/1/2^a	0/1/2^a	0/1/2^a

Medication (/kg) given intraperitoneally (ip) (once daily) or continuously in drinking water (po) after the creation of an esophagogastric anastomosis in rats. BPC 157 10 μg and 10 ng, L-NAME 5 mg, and L-arginine 100 mg given alone and/or combined intraperitoneally with the first application at 30 min after anastomosis creation and the last at 24 h before sacrifice. Drinking water alone (12 mL/d per rat) or BPC 157 in drinking water (10 μg, 10 ng/kg; 0.16 μg, 0.16 ng/mL) was provided continuously until sacrifice.

^aP < 0.05, at least vs control.

Citation: Djakovic Z, Djakovic I, Cesarec V, Madzarac G, Becejac T, Zukanovic G, Drmic D, Batelja L, Zenko Sever A, Kolenc D, Pajtak A, Knez N, Japjec M, Luetic K, Stancic-Rokotov D, Seiwerth S, Sikiric P. Esophagogastric anastomosis in rats: Improved healing by BPC 157 and L-arginine, aggravated by L-NAME. World J Gastroenterol 2016; 22(41): 9127-9140
URL: https://www.wjgnet.com/1007-9327/full/v22/i41/9127.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i41.9127