Basic Study
Copyright ©The Author(s) 2016.
World J Gastroenterol. Nov 7, 2016; 22(41): 9127-9140
Published online Nov 7, 2016. doi: 10.3748/wjg.v22.i41.9127
Table 1 Esophagitis score (0-5) Min/Med/Max in rats that underwent esophagogastric anastomosis
Medication (/kg) given ip (once time daily) or continuously in drinking water (po) after the creation of esophagogastric anastomosis in ratsEsophagitis score (0-5) Min/Med/Max in rats that underwent esophagogastric anastomosis
1 d2 d3 d4 d
Min/Med/MaxMin/Med/MaxMin/Med/MaxMin/Med/Max
Saline 5 mL4/4/44/4/44/4/44/4/4
BPC 157 10 μg0/1/2a0/1/2a0/1/2a0/1/2a
L-NAME 5 mg5/5/5a5/5/5a5/5/5a5/5/5a
L-arginine 100 mg0/1/2a1/2/3a1/2/3a1/2/3a
L-NAME 5 mg + L-arginine 100 mg2/3/4a0/1/2a1/2/3a1/2/3a
L-NAME 5 mg + BPC 157 10 μg1/2/3a1/2/3a0/1/2a0/1/2a
L-arginine 100 mg + BPC 157 10 μg0/1/2a0/1/2a0/1/2a0/1/2a
L-NAME 5 mg + L-arginine 100 mg +BPC 157 10 μg0/1/2a0/1/2a1/2/3a0/1/2a
BPC 157 10 ng0/1/2a0/1/2a0/1/2a0/1/2a
L-NAME 5 mg + BPC 157 10 ng1/2/3a2/3/4a1/2/3a0/1/2a
L-arginine 100 mg + BPC 157 10 ng0/1/2a0/1/2 a0/1/2a0/1/2a
L-NAME 5 mg + L-arginine 100 mg +BPC 157 10 ng1/2/3a0/1/2a1/2/3a0/1/2a
Drinking water4/4/44/4/44/4/44/4/4
12 mL/d per rat
BPC 157 10 μg0/1/2a0/1/2a0/1/2a0/1/2a
BPC 157 10 ng0/1/2a0/1/2a0/1/2a0/1/2a