Important considerations when contemplating endoscopic resection of undifferentiated-type early gastric cancer

Figure 4 Clinical example of the signet ring cell carcinoma associated with infiltrative intramucosal spread. A: An endoscopic image of an EGC, showing a flat lesion located in the lesser curvature of the lower body (circle). Endoscopically, the surrounding mucosa exhibited atrophic gastritis; B: After endoscopic resection, three of the lateral margins were positive (circle); C: Pathological findings after endoscopic resection (× 40). Signet ring cell carcinoma cells exhibited subepithelial spread. In other words, the lesion was of the infiltrative type (circle). Taken with permission from Gut Liver 2015; 9: 720-726[40].