Combination antiretroviral studies for patients with primary biliary cirrhosis

Figure 5 Incremental improvement of hepatic biochemistry observed in primary biliary cirrhosis patients maintained on UDCA receiving combination antiretroviral therapy with a protease inhibitor. Patients treated with daily lamivudine 150 mg (3TC) and zidovudine 300 mg (AZT) developed a 66 IU/mL mean reduction in ALP, whereas those receiving daily tenofovir/emtricitabine 300/200 mg (TDF, FTC) and lopinavir/ritonavir 800/200 mg (LPRr) for 6 mo (n = 13) experienced a mean ALP reduction of 114 IU/mL (two-way ANOVA, ^bP < 0.001, ^aP < 0.05 vs control). With permission, adapted from Mason et al[11].