Combination antiretroviral studies for patients with primary biliary cirrhosis

Figure 1 Hepatic immunohistochemistry study of NOD. c3c4 mice treated with placebo (A and B) or tenofovir/emtricitabine and lopinavir/ritonavir (C and D) for 12 wk. A: Mice receiving placebo showed anti-MMTV p27 Capsid reactivity in biliary epithelial cells and hepatocyte nuclei to a lesser extent; B: The distribution of anti-mitochondrial antibody staining was observed in a similar biliary distribution pattern on the bile duct epithelium; C and D: The reactivity to both viral and mitochondrial proteins was attenuated in mice treated with tenofovir/emtricitabine and lopinavir/ritonavir. Haematoxylin eosin staining, magnification × 2009 with × 4009 in insets showing staining in biliary epithelial cells. With permission from Sharon et al[8].