Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma

Figure 2 Diagrammatical representation of the PreS1/S2 deletion mutants. (Top) 3’-end PreS1 deletion mutant and (Bottom) 5’-end PreS2 deletion mutant are two common mutation forms found in HBV-induced HCC patients. Both mutants produce truncated large surface proteins (L’ and L”). M: Middle protein; S: Small protein. HBs gene nucleotide position 2848 to 835 as shown in Figure 1.