Gut microbiota and host metabolism in liver cirrhosis

Figure 2 Sub-networks showing correlation network differences from baseline to week 8 in placebo and in Lactobacillus GG groups separately centered on selected bacterial taxa. Color of nodes: Blue, inflammatory cytokine; light green, serum metabolites; dark green, urine metabolites. Color of edges: pink, negative remained negative but there is a net loss of negative correlation; dark blue, negative changed to positive; yellow, positive remained positive but there is a net loss of positive correlation; red, positive to negative; dark green, complete shift of negative to positive; military green, complete shift of positive to negative. A, B: Sub-networks of correlation changes centered around Enterobacteriaceae; C, D: Sub-networks of correlation changes centered around Clostridiales Incertae Sedis XIV; E, F: Sub-networks of correlation changes centered around Ruminococcaceae; G, H: Sub-networks of correlation changes centered around Lachnospiraceae. NSE: Neuron-specific enolase; IL: Interleukin; IFN: Interferon; LysoPC: Lysophosphatidylcholine; LysoPE: Lysophosphatidylethanolamine; ADMA: Asymmetricdimethylarginine; Rumino: Ruminococcaceae. Data adapted from Bajaj et al[69].