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©The Author(s) 2015.
World J Gastroenterol. Apr 21, 2015; 21(15): 4583-4591
Published online Apr 21, 2015. doi: 10.3748/wjg.v21.i15.4583
Published online Apr 21, 2015. doi: 10.3748/wjg.v21.i15.4583
Figure 3 Size distribution over time and representative microscopic images of non-hypervascular nodules that progressed without hypervascularity.
A: The median diameter of 73 non-hypervascular nodules (NHNs) was 9 mm [interquartile range (IQR): 8-12 mm] at the first detection. Diameter was plotted against time to show their growth/reduction rate during the study period. NHNs were classified into 3 groups based on vascularity and size changes in the observation period: hypervascular, enlarged and reduced groups. In the hypervascular group, the vascularity in the arterial phase was confirmed at the endpoint in each case. NHNs in the enlarged group grew at least 2 mm in diameter by the end of the observation, while the diameter decreased 2 mm or more in the reduced group; B: Tissue samples were obtained from 6 of 58 progressed NHNs. Most specimens show thick (1: case #21-1 allocated in supplementary Table 1) or thin (2: case #19-5 allocated in supplementary Table 1) trabecular patterns of tumor cells with nuclear crowding and hypercellularity, which were diagnosed as well-differentiated hepatocellular carcinoma (HCC). One specimen (3: case #22-1 allocated in supplementary Table 1) shows less-differentiated tumor cells with a vacuolated appearance and nuclear irregularity; it was diagnosed as moderately differentiated HCC. (H and E: Each scale bar represents 50 μm.)
- Citation: Kanefuji T, Takano T, Suda T, Akazawa K, Yokoo T, Kamimura H, Kamimura K, Tsuchiya A, Takamura M, Kawai H, Yamagiwa S, Aoyama H, Nomoto M, Terai S. Factors predicting aggressiveness of non-hypervascular hepatic nodules detected on hepatobiliary phase of gadolinium ethoxybenzyl diethylene-triamine-pentaacetic-acid magnetic resonance imaging. World J Gastroenterol 2015; 21(15): 4583-4591
- URL: https://www.wjgnet.com/1007-9327/full/v21/i15/4583.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i15.4583