MK-0626, a selective DPP-4 inhibitor, attenuates hepatic steatosis in ob/ob mice

Figure 3 Effect of MK-0626 on the mRNA expression of genes related to hepatic fatty acid metabolism from whole livers at the end of the 8-wk treatment period in each experimental group. The groups are the same as those shown in Figure 1. Total RNA extracted from liver tissues was used for mRNA expression analysis of peroxisome proliferator-activated receptor (PPAR)α, sterol regulatory element binding transcription factor (SREBP)-1c, stearoyl-CoA desaturase (SCD)-1, fatty acid synthase (FAS), microsomal triglyceride transfer protein (MTP) activity and carnitine palmitoyltransferase (CPT)-1. Results are expressed as the mean ± SD; n = 16 for each group. ^aP < 0.05, ^bP < 0.01 vs the lean group; ^cP < 0.05, ^dP < 0.01 vs the ob/ob group.