MK-0626, a selective DPP-4 inhibitor, attenuates hepatic steatosis in ob/ob mice

Figure 2 Assessment of hepatic histology and lipid content in the livers of ob/ob mice and their lean littermates at the end of an 8-wk treatment period. The groups are the same as those shown in Figure 1; A: Representative hepatic histology of lean, ob/ob, ob/ob + MK 1.5 and ob/ob + MK 3.0 groups. Liver sections were stained with Oil red O; B: Quantitative histomorphometric analysis for total lipid content of all hepatic histology for each experimental group. Oil red O-stained areas were quantified in 10 microscopic fields at a 400-fold magnification; C: Quantification of the lipid content of the liver from each experimental group. Results are expressed as the mean ± SD; n =16 for each group. ^bP < 0.01 vs the lean group; ^cP < 0.05, ^dP < 0.01 vs the ob/ob group.