Non-pulmonary allergic diseases and inflammatory bowel disease: A qualitative review

Figure 3 Histologic analysis of the colon in C57BL/6 mice. A: Normal architecture of the colonic mucosa from mice treated with 50% ethanol alone; B: Erosions of the epithelium, distortion of crypts, loss of goblet cells, and massive mononuclear cell infiltration in lamina propria in mice after administration of trinitrobenzene (TNBS); C-E: TNBS-induced colitis is dose-dependently improved by curcumin. Mice were treated with 0.5% (C), 2.0% (D), or 5.0% (E) curcumin just after administration of TNBS; F-H: Mice were treated with 2% curcumin in preventive mode (F), early therapeutic mode (G), or late therapeutic mode (H) (original magnification × 50). Reproduced with permission from reference Sugimoto et al[66].