Therapeutic options for the management of pancreatic cancer

Table 3 Therapies for the management of pancreatic cancer

Therapeutic option	Subset	Ref.
Surgical resection	Cephalic pancreatoduodenectomy Distal pancreatectomy Total pancreatectomy	Hidalgo[41]
Chemotherapy	Neoadjuvant Gemcitabine Adjuvant Gemcitabine 5-Fluorouracil Advanced disease Gemcitabine Gemcitabine + fluropyrimidines Gemcitabine + platinum analogs Gemcitabine + erlotinib FOLFIRINOX Nab-paclitaxel	Lemmens et al[101]; Gillen et al[102]; Neoptolemos et al[108]; Burris et al[118]; Heinemann et al[119]; Reni et al[120]; Moore et al[122]; Neesse et al[79]
Radiation therapy	Neoadjuvant Radiation + 5-fluorouracil Radiation + paclitaxel Proton beam radiation + capecitabine Adjuvant Radiation + 5-Fluorouracil Radiation + gemcitabine Radiation + chemotherapy Advanced Radiation + 5-fluorouracil Radiation + chemotherapy Stereotactic body radiotherapy	Pisters et al[131]; Hong et al[133]; Yeo et al[140]; Regine et al[138]; Neoptolemos et al[137]; Moertel et al[144]; Schellenberg et al[147]
Personalized therapy	Target specific point mutations Mitomycin C Immune system stimulation	Jones et al[77]; Villarroel et al[153]; Yanagimoto et al[154]