Bowman-Birk inhibitors from legumes as colorectal chemopreventive agents

Figure 1 Bowman-Birk family in legumes. A: Homology model of TI1, a major pea Bowman-Birk inhibitor (BBI) isoinhibitor, showing the trypsin and chymotrypsin inhibitory domains[33]; B: Amino acid sequence deduced from the TI1 gene from the pea cultivar Birte. The sequence of both inhibitory domains are underlined and the positions of the seven disulphide bonds are indicated by connecting lines[39]. K and Y at position P₁(*) determines specificity for trypsin and chymotrypsin, respectively.