Relationship between methylation and colonic inflammation in inflammatory bowel disease

Table 2 Relationship between methylation status and disease activity n (%)

Relationship	SLIT2 methylation (yes/no)	TFGB2 methylation (yes/no)
Endoscopic activity1
Activity	38/31 (55)	22/41 (35)
Remission	28/129 (18)	18/127 (12)
P value	< 0.001	< 0.001
Histological activity
Acute	26/20 (57)	7/29 (20)
Chronic	25/80 (24)	23/82 (22)
No activity	10/55 (15)	5/52 (9)
P value	< 0.001	NS
Clinical activity2
Active	5/0 (100)	2/2 (50)
Remission	35/22 (61)	21/30 (41)
P value	0.151	NS
Biological activity
Active (CRP ≥ 5 mg/L + FC ≥ 250 μg/g)	7/0 (100)	5/2 (71)
Remission (CRP < 5 mg/L + FC < 250 μg/g)	12/7 (63)	4/13 (24)
P value	0.134	0.061

¹Endoscopic activity was defined as Mayo > 0 for ulcerative colitis (UC) or Crohn’s disease (CD) activity index of severity (CDEIS) > 0 for CD. Endoscopic remission was defined as Mayo = 0 for UC or CDEIS = 0 for CD;

²Clinical activity, for UC patients symptomatic remission was defined as a Mayo stool frequency subscore of 0 or 1 and a Mayo rectal bleeding subscore of 0; and for CD patients as CD activity index < 150. CRP: C-reactive protein; FC: Faecal calprotectin; NS: Not significant.