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©2014 Baishideng Publishing Group Inc. All rights reserved.
Relationship between methylation and colonic inflammation in inflammatory bowel disease
Triana Lobatón, Daniel Azuara, Francisco Rodríguez-Moranta, Carolina Loayza, Xavier Sanjuan, Javier de Oca, Ana Fernández-Robles, Jordi Guardiola, Gabriel Capellá
Triana Lobatón, Francisco Rodríguez-Moranta, Jordi Guardiola, Department of Gastroenterology, University Hospital of Bellvitge, IDIBELL, Hospitalet de Llobregat, 08907 Barcelona, Spain
Daniel Azuara, Ana Fernández-Robles, Gabriel Capellá, Translational Research Laboratory, Catalan Institute of Oncology, IDIBELL, Hospitalet de Llobregat, 08907 Barcelona, Spain
Carolina Loayza, Xavier Sanjuan, Department of Pathology, University Hospital of Bellvitge, IDIBELL, Hospitalet de Llobregat, 08907 Barcelona, Spain
Javier de Oca, Department of Surgery, Colorectal Unit, University Hospital of Bellvitge, IDIBELL, Hospitalet de Llobregat, 08907 Barcelona, Spain
Author contributions: Lobatón T was the guarantor of the article; Ortega TL contributed to the study design, data collection, methylation analysis, statistical analysis, interpretation and manuscript writing; Azuara D contributed to the study design, methylation analysis, statistical analysis, interpretation and manuscript writing; Rodríguez-Moranta F contributed to the study design, colonoscopies, statistical analysis, interpretation and manuscript writing; Loayza C and Sanjuan X contributed to the histological analysis; de Oca J contributed to the study design, statistical analysis, interpretation and manuscript writing; Fernández-Robles A contributed to the methylation analysis; Guardiola J contributed to the study design, colonoscopies and sample collection; Capellá G contributed to the study design and manuscript writing.
Supported by Grants from Fondo de Investigación Sanitaria, FIS 12/01420; Ministerio de Ciencia e Innovación, SAF 09-07319, 12-33636; Fundació Gastroenterologia Dr. Francisco Vilardell, F05-01; Ministerio de Educación y Ciencia Spanish Networks RTICC, RD06/0020/0021, 1050 and 1051; RD12/0036/0031 and Fundación Científica de la Asociación Española contra el Cáncer Triana Lobaton supported by a grant from the Institut d’Investigació Biomédica de Bellvitge (IDIBELL)
Correspondence to: Triana Lobatón, MD, Department of Gastroenterology, University Hospital of Bellvitge, IDIBELL, Hospitalet del Llobregat, Gran Via 144, 08907 Barcelona, Spain. tlobaton@bellvitgehospital.cat
Telephone: +34-9-32607623 Fax: +34-9-32607603
Received: January 7, 2014
Revised: March 2, 2014
Accepted: April 21, 2014
Published online: August 14, 2014