CacyBP/SIP nuclear translocation induced by gastrin promotes gastric cancer cell proliferation

Figure 6 Inhibiting calcyclin binding protein/Siah-1 interacting protein nuclear translocation blocks proliferation of gastric cancer cells. A: Effects of gastrin on the viability of SGC7901-CacyBP/SIPsi1 and MKN45-CacyBP/SIPsi1 cells. The cells were treated with gastrin (10^-6-10^-10 mol/L) for 24 or 48 h, and their viability was determined by MTT assay. Columns, means; bars, mean ± SD of three separate experiments in which each treatment was done in 5 wells; B: Inhibiting CacyBP/SIP expression resulted in the decrease of anchorage-dependent growth and colony formation in SGC7901-CacyBP/SIPsi1 and MKN45-CacyBP/SIPsi1 cells with or without 10^-8 mol/L gastrin. CacyBP/SIP: Calcyclin binding protein/Siah-1 interacting protein.