CacyBP/SIP nuclear translocation induced by gastrin promotes gastric cancer cell proliferation

Figure 3 Calcyclin binding protein/Siah-1 interacting nuclear translocation is able to promote proliferation of gastric cancer cells. A: Effects of calcyclin binding protein/Siah-1 interacting protein (CacyBP/SIP) nuclear translocation on the proliferation of SGC7901 and MKN45 cells. As described in Materials and Methods, the cells were treated with gastrin (10^-6-10^-10 mol/L) for 24 or 48 h, and their viability was determined by MTT assay. Columns, means; bars, mean ± SD of three separate experiments in which each treatment was done in 5 wells; B: CacyBP/SIP nuclear translocation results in enhanced anchorage-dependent growth. Colony formation in SGC7901 and MKN45 cells with or without 10^-8 mol/L gastrin. ^aP < 0.05 vs control (without gastrin).