IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions

doi:10.3748/wjg.v20.i29.10050

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 7, 2014; 20(29): 10050-10061
Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10050

Table 4 Clinicopathological and molecular features of fifteen traditional serrated adenomas with high-grade dysplasia

No.	Age/sex	Location	Size (mm)	KRAS mutation	BRAF mutation	PIK3CA mutation	MGMT methylation	MLH1 methylation	MSI status	LINE-1 methylation level	IGF2 DMR0 methylation level	IGF2 expression
1	75/M	Rectum	8	c.35G>A (p.G12D)	Wild	Wild	(-)	(-)	MSS/MSI-low	58	70	Weak
2	54/F	Sigmoid colon	20	c.35G>A (p.G12D)	Wild	Wild	(+)	(-)	MSS/MSI-low	53.7	39.5	Strong
3	62/F	Transverse colon	15	c.38G>A (p.G13D)	Wild	Wild	(+)	(-)	MSS/MSI-low	53.3	72.0	No expression
4	84/M	Rectum	5	c.35G>A (p.G12D)	Wild	Wild	(-)	(-)	MSS/MSI-low	65.0	26.5	Moderate
5	85/M	Sigmoid colon	12	Wild	c.1799T>A (p.V600E)	Wild	(-)	(-)	MSS/MSI-low	58.0	45.5	Strong
6	48/M	Sigmoid colon	20	Wild	c.1799T>A (p.V600E)	Wild	(-)	(-)	MSS/MSI-low	53.7	40.5	Moderate
7	69/M	Sigmoid colon	10	Wild	c.1799T>A (p.V600E)	Wild	(-)	(-)	MSS/MSI-low	58.7	52.0	No expression
8	60/M	Descending colon	9	Wild	c.1799T>A (p.V600E)	Wild	(-)	(-)	MSS/MSI-low	59.0	41.5	Moderate
9	34/M	Sigmoid colon	18	Wild	c.1799T>A (p.V600E)	Wild	(+)	(-)	MSS/MSI-low	57.3	42.0	Strong
10	61/M	Rectum	10	Wild	c.1799T>A (p.V600E)	Wild	(-)	(-)	MSS/MSI-low	56.7	29.0	Strong
11	52/F	Ascending colon	15	Wild	c.1799T>A (p.V600E)	Wild	(+)	(+)	MSS/MSI-low	57.0	57.0	Moderate
12	70/F	Rectum	13	Wild	c.1799T>A (p.V600E)	Wild	(+)	(+)	MSS/MSI-low	63.0	84.5	Weak
13	66/F	Ascending colon	12	Wild	Wild	c.1624G>A (p.E542K)	(-)	(-)	MSS/MSI-low	49.7	28.0	Moderate
14	52/M	Sigmoid colon	12	Wild	Wild	Wild	(-)	(-)	MSS/MSI-low	48.0	44.5	Moderate
15	69/F	Rectum	13	Wild	Wild	Wild	(+)	(-)	MSS/MSI-low	44.3	80.0	Weak

HGD: High-grade dysplasia; MSI: Microsatellite instability; MSS: Microsatellite stable; TSA: Traditional serrated adenoma.

Citation: Naito T, Nosho K, Ito M, Igarashi H, Mitsuhashi K, Yoshii S, Aoki H, Nomura M, Sukawa Y, Yamamoto E, Adachi Y, Takahashi H, Hosokawa M, Fujita M, Takenouchi T, Maruyama R, Suzuki H, Baba Y, Imai K, Yamamoto H, Ogino S, Shinomura Y. IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions. World J Gastroenterol 2014; 20(29): 10050-10061
URL: https://www.wjgnet.com/1007-9327/full/v20/i29/10050.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i29.10050