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©2014 Baishideng Publishing Group Inc. All rights reserved.
IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions
Takafumi Naito, Katsuhiko Nosho, Miki Ito, Hisayoshi Igarashi, Kei Mitsuhashi, Shinji Yoshii, Hironori Aoki, Masafumi Nomura, Yasutaka Sukawa, Eiichiro Yamamoto, Yasushi Adachi, Hiroaki Takahashi, Masao Hosokawa, Masahiro Fujita, Toshinao Takenouchi, Reo Maruyama, Hiromu Suzuki, Yoshifumi Baba, Kohzoh Imai, Hiroyuki Yamamoto, Shuji Ogino, Yasuhisa Shinomura
Takafumi Naito, Katsuhiko Nosho, Miki Ito, Hisayoshi Igarashi, Kei Mitsuhashi, Eiichiro Yamamoto, Yasushi Adachi, Yasuhisa Shinomura, Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, Sapporo 060-8543, Japan
Shinji Yoshii, Hiroaki Takahashi, Department of Gastroenterology, Keiyukai Sapporo Hospital, Sapporo 003-0027, Japan
Hironori Aoki, Masafumi Nomura, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-0811, Japan
Yasutaka Sukawa, Shuji Ogino, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, United States
Masao Hosokawa, Department of Surgery, Keiyukai Sapporo Hospital, Sapporo 003-0027, Japan
Masahiro Fujita, Toshinao Takenouchi, Department of Pathology, Keiyukai Sapporo Hospital, Sapporo 003-0027, Japan
Reo Maruyama, Hiromu Suzuki, Department of Molecular Biology, Sapporo Medical University School of Medicine, Sapporo 060-8543, Japan
Yoshifumi Baba, Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto 860-0862, Japan
Kohzoh Imai, Division of Cancer Research, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
Hiroyuki Yamamoto, Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan
Author contributions: Naito T and Nosho K designed the research, analyzed the data and wrote the manuscript; Sukawa Y, Adachi Y, Yamamoto E, Maruyama R and Suzuki H analyzed the data; Naito T, Ito M, Igarashi H and Mitsuhashi K performed experiments; Yoshii S, Aoki H, Nomura M, Takahashi H, Hosokawa M, Fujita M and Takenouchi T provided the collection of the human material and analyzed the data; Baba Y, Imai K, Yamamoto H, Ogino S and Shinomura Y edited the manuscript; Nosho K and Ogino S helped interpretation and drafting of this manuscript.
Supported by The Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research, grant No. 23790800 (to Nosho K) and 23390200 (to Shinomura Y); A-STEP (Adaptable and Seamless Technology Transfer Program through Target-driven R and D) (to Nosho K); Daiwa Securities Health Foundation (to Nosho K); Kobayashi Foundation for Cancer Research (to Nosho K); Sagawa Foundation for Promotion of Cancer Research (to Nosho K); Suzuken Memorial Foundation (to Nosho K), and Takeda Science Foundation (to Nosho K); and USA National Institute of Health, grant number R01 CA151993 (to Ogino S)
Correspondence to: Katsuhiko Nosho, MD, PhD, Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, S-1, W-16, Chou-ku, Sapporo 060-8543, Japan. nosho@sapmed.ac.jp
Telephone: +81-11-6112111 Fax: +81-11-6112282
Received: January 11, 2014
Revised: March 1, 2014
Accepted: April 21, 2014
Published online: August 7, 2014
